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A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants

NCT07673601 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2026-06-29

No results posted yet for this study

Summary

This study aims to find out how much adimanebart gets into the blood circulation of healthy adults. Researchers will measure the amount of adimanebart in blood over time to learn how it moves through the body. The drug's safety will also be assessed.

The participants will be assigned to one of 3 parts of the study: part 1 investigates the absolute bioavailability; part 2 investigates the effect of different body weights on adimanebart in blood after subcutaneous (SC) dosing; part 3 investigates formulation adaptations.

Participants will be in the study for approximately up to 24 weeks.

Conditions

  • Healthy Volunteers (HV)
  • Healthy Volunteer

Interventions

BIOLOGICAL

Adimanebart IV

Intravenous infusion of adimanebart IV

BIOLOGICAL

Adimanebart SC - formulation A

Subcutaneous administration of Adminanebart SC

BIOLOGICAL

Adimanebart SC - formulation B

Subcutaneous administration of Adminanebart SC

BIOLOGICAL

Adimanebart SC - formulation C

Subcutaneous administration of Adminanebart SC

Sponsors & Collaborators

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-12
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07673601 on ClinicalTrials.gov