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Efficacy of Islet Re-transplantation After Failure of Beta-cell Replacement

NCT07666789 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2026-06-24

No results posted yet for this study

Summary

Islet transplantation and pancreas transplantation are established therapeutic options for selected individuals with type 1 diabetes experiencing severe glycemic instability and recurrent hypoglycemia. Although these approaches significantly improve glycemic management and quality of life, long-term graft survival remains limited, with a progressive decline in beta-cell function over time.

The clinical benefit-risk profile of islet re-transplantation after graft failure remains poorly defined, and outcomes following repeat islet transplantation after prior islet graft failure have not been specifically evaluated.

Repeated exposure to multiple donors may increase the risk of alloimmunization, including the development of donor-specific antibodies , which may adversely affect graft survival and limit access to future transplantation.

This multicenter retrospective cohort study aims to evaluate the efficacy and safety of islet re-transplantation in adults with type 1 diabetes after failure of initial beta-cell replacement (islet or pancreas transplantation), with outcomes assessed at 3 months, 1 year, and 5 years.

Conditions

  • Type 1 Diabetes (T1D)
  • Islets of Langerhans Transplantation

Sponsors & Collaborators

  • University Hospital, Grenoble

    collaborator OTHER

  • University Hospital, Toulouse

    collaborator OTHER

  • University Hospital, Strasbourg

    collaborator OTHER

  • University Hospital, Lille

    collaborator OTHER

  • University Hospital, Paris

    collaborator OTHER

  • The Civil Hospitals, Lyon

    collaborator UNKNOWN

  • University Hospital, Montpellier

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-31
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07666789 on ClinicalTrials.gov