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rTMS and Olfactory Training for Parkinson's Disease

NCT07666477 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-06-26

No results posted yet for this study

Summary

Background:

Olfactory and gustatory impairments are common clinical manifestations in patients with neurodegenerative conditions like Parkinson's disease. These chemosensory deficits significantly impact the quality of life, often preceding motor symptoms. Currently, there is a need for effective non-invasive interventions to improve sensory recovery.

Objective:

The primary objective of this study is to evaluate the therapeutic efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) combined with olfactory training in restoring chemosensory function. We aim to determine whether this combined approach provides superior outcomes compared to individual therapies or standard care.

Methods:

This clinical trial involves 120 patients diagnosed with Parkinson's disease. Participants will be randomized into four groups to receive either combined rTMS and olfactory training, isolated rTMS, isolated olfactory training, or a control intervention. The recovery of olfactory function will be measured using validated sensory testing tools (such as Sniffin' Sticks) and Electrogustometry (EGM) to assess neural pathway improvement.

Conclusion/Significance:

This study aims to provide evidence-based insights into non-invasive neurological rehabilitation for chemosensory dysfunction. The findings may help optimize personalized treatment protocols for patients suffering from sensory impairment, potentially enhancing their overall cognitive and sensory quality of life.

Conditions

  • Parkinson Disease (PD)
  • Olfactory Dysfunction

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

High-frequency (10 Hz) rTMS stimulation (2000 pulses per session) targeted at cortical olfactory regions.

BEHAVIORAL

Structured Olfactory Training

Daily structured olfactory training protocol using standardized odorants (twice daily).

DEVICE

Sham rTMS

Sham stimulation delivered using an identical coil setup without neural activation.

Sponsors & Collaborators

  • Batman University

    collaborator OTHER

  • Mustafa Baran

    lead OTHER

Principal Investigators

  • Mustafa BARAN, PhD · Batman University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-02
Primary Completion
2026-05-15
Completion
2026-05-21

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07666477 on ClinicalTrials.gov