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Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)

NCT07663578 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-06-23

No results posted yet for this study

Summary

The goal of this clinical trial is to learn how a non-invasive brain stimulation method called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking in adults. TIEFS uses electrical currents applied to the scalp to influence brain activity without surgery.

The main questions this study aims to answer are:

* How does TIEFS change brain signals measured with brain recordings?
* Does TIEFS affect thinking abilities such as memory, language, movement, or perception?
* Is TIEFS safe and well tolerated when used in people?

This study includes two groups of participants. One group includes adults with epilepsy who are already undergoing specialized brain monitoring as part of their medical care. The other group includes healthy adults with no history of seizures.

Participants will:

* Receive brief sessions of TIEFS using electrodes placed on the scalp
* Complete computer-based tasks that test memory, attention, language, or movement. Answer questions about how the stimulation feels
* Have brain activity recorded during the study

Each study visit lasts up to three hours and may occur in one or two sessions. Information from this study may help researchers better understand the human brain and support the development of future non-invasive brain stimulation treatments.

Conditions

Interventions

DEVICE

Temporal Interference Electrical Stimulation

Temporal Interference Electrical Stimulation (TIEFS) is a non-invasive brain stimulation technique that uses two high-frequency electrical fields (\>1 kHz) to generate an interference pattern at a specific brain region, creating a low-frequency envelope (Δf = f2 - f1) at the target depth. Unlike traditional stimulation methods, which affect only superficial brain regions, TIEFS can reach deeper structures without the need for implanted electrodes. The stimulation is applied through scalp electrodes. It has the potential for targeted brain interventions in both functional studies and clinical applications for neurological conditions.

Sponsors & Collaborators

Principal Investigators

  • Nigel P Pedersen, MBBS · University of California Davis, School of Medicine, Neurology Department

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-16
Primary Completion
2027-04-15
Completion
2027-04-15
FDA Device
Yes

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07663578 on ClinicalTrials.gov