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Tackling Resistance And HealthCare Economics Through CPE Screening

NCT07663110 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 16000

Last updated 2026-06-23

No results posted yet for this study

Summary

The goal of this clinical study is to learn if it is possible to reduce the spread of resistant bacteria called CPEs (Carbapenemase producing Enterobacterales) between patients admitted to hospital.

CPEs can be carried in the gut of people without making them ill. Normally when patients come into hospital, they may undergo a swab test on their bottom to see if CPEs can be grown. This test can take up to 24 hours to produce a result.

The investigators want to use a faster test which takes 2 hours to produce a result, and whether this can make a difference to CPE spread between person to person.

The main questions it aims to answer are:

1. Why do people carry, transmit or get infected with CPE?
2. If a faster test was used to look for CPE, would this be better at reducing patient spread in hospital?
3. Is a faster test also more cost effective?

Participants will:

1. Be tested by both the usual and faster test when they come into hospital by a swab on their bottom
2. Where they test positive for CPE they will be asked to answer some questions about their health

Conditions

  • Carbapenem-Resistant Enterobacteriaceae
  • Colonisation

Interventions

DIAGNOSTIC_TEST

Rapid molecular diagnostic test for CPE identification

Participants will undergo a rectal swab and undergo rapid molecular testing for CPE colonisation

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Jon Otter · Guy's and St Thomas NHS Trust

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2027-11-01
Completion
2028-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07663110 on ClinicalTrials.gov