Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition Intervention

Summary

The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation. Although many non-pharmacological recommendations exist, it is unclear which methods are suitable for which individuals.

This randomized study aims to compare the effectiveness of individualized dietary recommendations (Gustabor group) with the current standard of care -general recommendations (Control group). Participants will undergo an objective assessment of taste disorders using taste strips and questionnaires. Based on the results, the Gustabor group will receive both general and specific dietary suggestions. These will be accomapnied by AI-generated recipe suggestions tailored to specific taste disorders (e.g., more cold foods in cases of metallic taste). The control group will receive the current standard: a flyer containing general dietary advice for oncology patients previously shown to be beneficial for managing taste alterations. The primary endpoint is the PG-SGA score within 12 weeks of inclusion.

Conditions

• Multiple Myeloma (MM)
• GI Cancer
• Taste Disorder
• Melanoma (Skin Cancer)
• Urogenital Cancers

Interventions

OTHER

Gustabor server

AI based web platform providing individual lifestyle tips and recipe recommendations based on the patient's individual data and taste disorder

OTHER

Standard Recommendations

Flyer consisting of current standard recommendations for taste disorders from scientifically published measures

Sponsors & Collaborators

• LMU Klinikum

  collaborator OTHER

• University Hospital Regensburg

  collaborator OTHER

• University Hospital Erlangen

  collaborator OTHER

• University Hospital Augsburg

  collaborator OTHER

• TUM Klinikum

  collaborator UNKNOWN

• Wuerzburg University Hospital

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-07-24

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• Germany

Study Locations