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Corpus Luteum Function and Cardiovascular Adaptation in a Natural MOCK Cycle.

NCT07648381 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 118

Last updated 2026-06-15

No results posted yet for this study

Summary

In infertility treatment, embryos are created in vitro after eggs have been fertilised by sperm using in vitro fertilisation or intracytoplasmic sperm injection techniques. These embryos, resulting from hormonal ovarian stimulation, can be transferred shortly after egg retrieval (fresh transfer) or frozen for later use. Both natural menstrual cycles and artificial cycles (using hormones to mimic a normal cycle) can prepare the uterus for embryo transfer. Patients with regular menstrual cycles often prefer the non-medicated approach. However, these cycles offer less flexibility in timing because they rely on ovulation. As the number of FET cycles increases worldwide, scientists are exploring the possibility of inducing ovulation in smaller follicles to increase the flexibility of natural cycles. However, the safety for future pregnancies is unknown. This study aims to better understand the function of the corpus luteum, the follicle remnant in the ovary after ovulation, by measuring several factors that change throughout the cycle due to substances produced by the corpus luteum. The results of the study will have a direct impact on clinical practice by increasing the flexibility of frozen transfer cycles.

Conditions

  • Menstrual Cycle
  • Luteal Phase Progesterone Levels
  • Luteal Phase Adaptation
  • MOCK Cycle

Interventions

DIAGNOSTIC_TEST

Mean Arterial Pressure measurement.

The MAP will be measured at cycle day 7 and 7 days post-ovulation induction to follow cardiovascular adaptations.

DIAGNOSTIC_TEST

Blood samples for the analysis of biomarkers.

We will collect several blood samples: * One at day 8 of the cycle: measurements of P, E2, Na, K, CL, CO2, Osmolality, PRL, direct renin, PAC, Nt-proBNP, Relaxin-2 and VEGF. * One for cycle follow up between day 8 and ovulation: measurement of P, E2, LH * One at day 7 after ovulation induction: measurements of P, E2, Na, K, CL, CO2, Osmolality, PRL, direct renin, PAC, Nt-proBNP, Relaxin-2 and VEGF.

DIAGNOSTIC_TEST

Transvaginal ultrasound for follicle and endometrium measurements.

A transvaginal ultrasound will be performed after day 8 of the cycle to evaluate a 2D measurement of the growing follicle, as well as a measurement of the endometrial thickness to evaluate readiness for ovulation induction.

DRUG

Ovitrelle injection for ovulation induction

When patient is deemed ready for ovulation based on follicle size, blood results and endometrium, she will be asked to inject Ovitrelle 250 micrograms to induce ovulation in a controlled and timed manner.

Sponsors & Collaborators

  • Universitair Ziekenhuis Brussel

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2028-02-29
Completion
2028-09-30

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07648381 on ClinicalTrials.gov