Single and Multiple Dose Study to Evaluate Safety and Pharmacokinetics of BMS-986533 in Healthy Participants and Assessments of Food and pH Effects on Relative Bioavailability, and Drug-Drug Interaction Potential in Healthy Participants
NCT07629999 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 136
Last updated 2026-07-24
Summary
The purpose of this study is to evaluate the safety and pharmacokinetics of BMS-986533 in healthy participants receiving single and multiple doses, to assess food and pH effects on the relative bioavailability of BMS-986533, and the P-gp and BCRP-mediated drug-drug interaction potential of the study drug
Conditions
- Healthy Volunteers
Interventions
- DRUG
-
BMS-986533
Specified dose on specified days
- DRUG
-
Famotidine
Specified dose on specified days
- DRUG
-
Specified dose on specified days
- DRUG
-
Dabigatran Etexilate
Specified dose on specified days
- DRUG
-
Rosuvastatin
Specified dose on specified days
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Bristol-Myers Squibb · Bristol-Myers Squibb
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2026-07-13
- Primary Completion
- 2027-06-01
- Completion
- 2027-06-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
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