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Prenatal Androgen and Skills

NCT07627113 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 94

Last updated 2026-06-04

No results posted yet for this study

Summary

Due to the difficulties and risks of directly measuring prenatal hormone levels, biomarkers that indirectly reflect this exposure are used in research. In this context, the ratio of second to fourth finger length (2D:4D) is widely preferred because it is an easily applicable and non-invasive measurement. Evidence shows that 2D:4D stabilizes from the second trimester of pregnancy onward and exhibits strong sex differences across populations. The 2D:4D ratio is generally lower in men than in women. 2D is more strongly influenced by prenatal estrogen, while 4D is more strongly influenced by prenatal testosterone; this occurs during the first trimester of intrauterine fetal development. To our knowledge, studies examining the relationship between the 2D:4D ratio, an indirect indicator of prenatal androgen exposure, and dexterity and tactile discrimination are limited. Accordingly, the planned study aims to evaluate the relationship between the 2D:4D ratio and fine motor skills and tactile discrimination in healthy young adults.

Conditions

  • Health Adults

Interventions

OTHER

Digit Ratio

The second (2D) and fourth (4D) finger lengths of the participants will be measured separately in both hands by a physiotherapist with over thirteen years of clinical experience.

BEHAVIORAL

Fine motor skills

Hand dexterity will be assessed using the Purdue Pegboard Test. The test will be administered according to standard procedure with participants seated at a table. Participants will be asked to place the pegs into the corresponding holes as quickly and accurately as possible within a specified time (30 seconds).

BEHAVIORAL

Tactile Discrimination

To perform the 2-point discrimination tests, the Baseline® two-point discriminator will be used. Measurements will be applied to the distal phalangeal pulp of the index finger on both hands while participants are seated in a comfortable position with their eyes closed.

Sponsors & Collaborators

  • Nigde Omer Halisdemir University

    lead OTHER

Principal Investigators

  • Rabia ZORLULAR · Nigde Omer Halisdemir University

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2027-07-01
Completion
2027-07-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07627113 on ClinicalTrials.gov