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Hamstring Strengthening in Hypermobile Conditions

NCT07626957 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-06-04

No results posted yet for this study

Summary

The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS). The main questions it aims to answer are:

* Does hamstring strengthening reduce the looseness of the knee joint in HSD/hEDS?
* Does hamstring strengthening improve clinical outcomes like pain in people living with HSD/hEDS?

Participants will:

* Attend two exercise classes per week for 12 weeks.
* Visit the laboratory every 4-6 weeks for testing.

Conditions

  • Hypermobile EDS (hEDS)
  • Hypermobile Ehlers-Danlos Syndrome
  • Hypermobile Spectrum Disorder
  • Hypermobility Type Ehlers-Danlos Syndrome

Interventions

BEHAVIORAL

Progressive resistance exercise with an emphasis on eccentric hamstring loading.

The exercise intervention consists of a 12-week supervised lower limb strengthening program focused on eccentric hamstring loading. This program is adapted from a lower limb progressive resistance training protocol that was well-tolerated and effective in people with HSD/hEDS. Each exercise session will start with a 10-minute aerobic warm up. This will be followed by the lower limb strengthening exercises, and a 5-minute aerobic cooldown. The lower limb exercises will include forward lunges and seated machine weights (leg press, leg extension, leg curl, calf raise). At weeks 6-11, eccentric hamstring loading will be initiated by utilizing the 2:1 technique of two limbs performing concentric action at once and then a single limb performing the eccentric action in a seated leg curl machine. This is an established eccentric loading protocol for the hamstring muscle group.

Sponsors & Collaborators

Principal Investigators

  • Ranita Manocha · University of Calgary

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2027-05-01
Completion
2027-08-01

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07626957 on ClinicalTrials.gov