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Dermocosmetic Evaluation of Propolis Ointments in Atopic-Prone Dry Skin

NCT07618234 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-06-01

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if propolis ointments work to improve dry, atopic-prone skin in adults. Propolis is a natural substance made by honeybees. It will also learn about the safety of these ointments.

The main questions it aims to answer are:

Does propolis ointment lower dryness, scaling, and roughness better than a base ointment with no propolis? Is there a difference between crude propolis and ethanolic extract of propolis (EEP)?

Researchers will compare three ointments to see if they improve skin condition:

A propolis ointment made with 3% ethanolic extract A propolis ointment made with 5% crude propolis A base ointment with no propolis (look-alike)

Participants will:

Apply the ointment to dry skin areas twice a day for 4 weeks Visit the clinic 4 times: for screening, at the start, at week 2, and at week 4 Have their skin checked by a researcher using a standard dryness score Answer questions about skin comfort, itching, and satisfaction Have a patch test before starting to check for allergy to propolis

Conditions

Interventions

OTHER

Ethanolic extract of propolis

3% ethanolic extract of propolis in ointment base

OTHER

Crude propolis

5% micronized crude propolis in ointment base

OTHER

Vehicle ointment

Ointment base without propolis

Sponsors & Collaborators

  • Manara University

    lead OTHER

Principal Investigators

  • Mahmoud Bitar, BPharm St. · Manara University

  • Haya Farhat, BPharm St. · Manara University

  • Nagham Saleh, BPharm St. · Manara University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-15
Primary Completion
2026-05-24
Completion
2026-06-30

Countries

  • Syria

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07618234 on ClinicalTrials.gov