Rectosigmoid Lesion Excision vs. Resection: A Non-Inferiority Randomized Comparison in Advanced Ovarian Cancer

Summary

Colorectum is the most common site of metastasis in ovarian cancer. Regarding intestinal surgery, there is controversy over whether to choose bowel resection or tumor removal, and currently, there are no prospective randomized controlled studies comparing the oncological safety of these two surgical approaches. This study is a prospective randomized trial aimed at comparing the efficacy of rectosigmoid resection versus rectosigmoid-preserving lesion excision in advanced ovarian cancer surgery.

Conditions

• Ovarian Cancer (OvCa)

Interventions

PROCEDURE

Rectosigmoid Lesion Excision +tumor cell debulking surgery

Surgery for pelvic rectosigmoid tumors

PROCEDURE

Rectosigmoid Resection +tumor cell debulking surgery

Rectosigmoid Resection +tumor cell debulking surgery

Sponsors & Collaborators

• Tongji Hospital

  collaborator OTHER

• Zhejiang University

  collaborator OTHER

• Zhejiang Provincial People's Hospital

  collaborator OTHER

• Zhejiang Cancer Hospital

  collaborator OTHER

• Huzhou Central Hospital

  collaborator OTHER

• Ningbo Women & Children's Hospital

  collaborator OTHER

• Shaoxing People's Hospital

  collaborator OTHER

• The Central Hospital of Lishui City

  collaborator OTHER

• Women's Hospital School Of Medicine Zhejiang University

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-01-10

Primary Completion

2028-12-31

Completion

2028-12-31

Countries

• China

Study Locations