STAGE-MTC Trial Thyroid Lobectomy With Ipsilateral Central Neck Dissection

Summary

This clinical trial studies how well thyroid lobectomy with ipsilateral central neck dissection works to treat medullary thyroid cancer (MTC) in patients without a germline RET mutation (sporadic). Currently, sporadic and germline RET (rearranged during transfection) mutation positive MTCs that are limited to the thyroid are managed in the same way, complete surgical removal of the entire thyroid gland (total thyroidectomy) with surgical removal of lymph nodes and other tissues on both sides of the neck (bilateral central neck dissection). Total thyroidectomy and bilateral central neck dissection carry a high risk of complications, and total thyroidectomy requires patients to take lifelong thyroid hormone replacement therapy, which can impact quality of life. Research has shown that patients with sporadic MTC do not have a high risk of developing MTC in the remaining normal thyroid tissue and that they may be able to be managed differently than patients with germline RET mutations. Thyroid lobectomy with ipsilateral central neck dissection is a surgical procedure which removes only the lobe of the thyroid gland that is affected by cancer as well as the lymph nodes and other tissues from the affected side of the neck. Thyroid lobectomy with ipsilateral central neck dissection may be a safer, more tolerable, and/or more effective way to treat sporadic MTC.

Conditions

• Thyroid Gland Medullary Carcinoma

Interventions

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

FDG-Positron Emission Tomography and Computed Tomography Scan

Undergo FDG PET/CT

PROCEDURE

Ga-68 PET/CT Scan

Undergo Ga-68 PET/CT

PROCEDURE

Neck Dissection

Undergo unilateral central neck dissection

PROCEDURE

Neck Dissection

Undergo contralateral neck dissection

BEHAVIORAL

Surveillance

Undergo routine cancer surveillance

PROCEDURE

Thyroid Lobectomy

Undergo thyroid lobectomy

PROCEDURE

Thyroidectomy

Undergo completion thyroidectomy

PROCEDURE

Ultrasound Imaging

Undergo neck ultrasound

Sponsors & Collaborators

• Eli Lilly and Company

  collaborator INDUSTRY

• Jonsson Comprehensive Cancer Center

  lead OTHER

Principal Investigators

• James Wu, MD · UCLA / Jonsson Comprehensive Cancer Center

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-09-02

Primary Completion

2031-09-02

Completion

2032-04-21

Countries

• United States

Study Locations