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The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time

NCT07611344 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2026-05-28

No results posted yet for this study

Summary

This clinical trial aims to help us understand how two drugs, Propofol and Remazoloam, affect when researchers remove a Participants' breathing tube after liver surgery (laparoscopic liver resection).The main research questions include: comparing the time to breathing tube removal between patients who receive each drug, comparing changes in heart rate and blood pressure during surgery, and comparing the rates of unwanted medical events after surgery. Researchers will give either Propofol or Remimazolam as a sedative medicine for anesthesia. This will allow the researchers to compare the time to breathing tube removal after surgery. Participants will complete their surgery according to a pre-planned surgical plan.

Conditions

  • Laparoscopic Hepatectomy

Interventions

DRUG

Remimazolam

Anesthesia induction: Intravenous injection of remimazolam 0.2-0.4 mg/kg. Anesthesia maintenance: Continuous infusion of remimazolam at 0.4-0.7mg/kg/h.

DRUG

propofol

Anesthesia induction: Intravenous injection of propofol 1.5-2.5 mg/kg. Anesthesia maintenance: Continuous infusion of propofol at 4-10 mg/kg/h.

Sponsors & Collaborators

  • Xuyu Zhang

    lead OTHER

Principal Investigators

  • Xuyu Zhang, M.D. · Department of Anesthesiology,The first affiliated hospital of Sun Yat-sen University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2026-12-01
Completion
2026-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07611344 on ClinicalTrials.gov