Evaluating the Feasibility of Prehabilitation Delivery Models for Patients Preparing for Ovarian Cancer Surgery

Summary

The goal of this clinical trial is to learn whether high-dose multimodal prehabilitation, delivered either in person or remotely with coaching and web application support, is feasible and acceptable for women preparing for ovarian cancer surgery. It will also examine which delivery model patients prefer and the factors influencing patient preferences.

The main questions ADAPT-OC aims to answer are:

1. Can participants achieve the prescribed aerobic exercise target of at least 10 MET-hours per week before surgery?
2. Do patients prefer in-person prehabilitation, remote prehabilitation, or education-only care, and what factors influence that preference?

The researchers will compare in-person prehabilitation, remote prehabilitation, and education-only care to see which delivery approach is most feasible, acceptable, and practical for patients with suspected ovarian cancer.

Participants will:

* Choose their preferred study group, or be randomly assigned if they have no preference
* Complete physical assessments, questionnaires, and interviews at baseline, 1-3 days before surgery, and 4 weeks after surgery
* If assigned to a prehabilitation group, complete aerobic exercise, protein supplementation, and daily breathing exercises before surgery
* Attend weekly coaching sessions with a trained prehabilitation coach
* Use the KingstonPrehab web application to track exercise, nutrition, breathing practice, and progress toward activity goals

Conditions

• Prehabilitation
• Preoperative Aerobic Training
• Preoperative Care
• Ovarian Cancer
• Exercise Therapy
• Postoperative Outcomes

Interventions

BEHAVIORAL

Multimodal Prehabilitation Program

The multimodal prehabilitation program consists of progressive aerobic exercise targeting at least 10 MET-hours/week above baseline via 3-5 sessions per week, daily protein supplementation (BOOST Carb Smart; Nestlé Canada Inc.; North York, Ontario, Canada), daily box breathing for stress management, weekly one-on-one behavioural coaching sessions with a trained prehabilitation coach, and use of the KingstonPrehab web application for self-monitoring and progress tracking. Aerobic exercise sessions will be supervised on site. This intervention is delivered either in-person or remotely depending on study arm allocation.

OTHER

Educational Materials

Participants receive standardized educational materials describing the principles of prehabilitation, including aerobic exercise, resistance exercise, nutrition focusing on perioperative protein intake, and stress management strategies. Participants will also receive a postoperative recovery handbook adapted from the Montreal General Hospital Prehabilitation Clinic that provides guidance on nutrition, pain and constipation management, mobilization, in-hospital exercise, and a progressive return-to-activity plan for the first 8 weeks after surgery.

Sponsors & Collaborators

• Kingston Health Sciences Centre

  collaborator OTHER

• Queen's University

  collaborator OTHER

• Jordan Leitch

  lead OTHER

Principal Investigators

• Jordan Leitch, MSc, MD, FRCPC · Queen's University

Study Design

Allocation

NON_RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-14

Primary Completion

2027-05-14

Completion

2027-05-14

Countries

• Canada

Study Locations