Physiatry-Led Cancer Prehabilitation During Neoadjuvant Systemic Therapy to Improve Function in Stage III-IVA Gynecologic Cancer Patients

Summary

This clinical trial studies whether physiatry-led cancer prehabilitation can be used during systemic treatment before surgery (neoadjuvant systemic treatment \[NST\]) to improve function in stage III-IVA gynecologic cancer patients. Treatment of gynecologic cancers presents significant challenges to physical and mental health and patients often experience many challenges following treatment including sleep disturbance, extreme tiredness, sexual dysfunction, and bowel and urinary problems. Patients who have low functioning prior to surgery often have worse outcomes following surgery; however, services to support functional shortages often start after surgery. Physiatry-led cancer prehabilitation is a strategy aimed at reducing post-treatment functional challenges by improving physical and mental function before treatment. It involves physiatry, which is a medical specialty focused on function. Physiatry involvement in prehabilitation allows for the evaluation and management of co-existing conditions, medical supervision, and the coordination of complex plans involving multiple teams. Using physiatry-led cancer prehabilitation during NST may be an effective way to improve function in stage III-IVA gynecologic cancer patients.

Conditions

• Malignant Female Reproductive System Neoplasm

Interventions

OTHER

Educational Intervention

Receive written prehabilitation education materials

OTHER

Goal Setting

Follow and meet prehabilitation goals

OTHER

Interview

Ancillary studies

OTHER

Referral

Receive tailored multidisciplinary referrals

PROCEDURE

Rehabilitation

Attend cancer physiatry consultation

OTHER

Supportive Care

Receive resistance bands, nutritional guidance sources, and tips and resources

OTHER

Survey Administration

Ancillary studies

PROCEDURE

Tailored Intervention

Receive starter prescription

Sponsors & Collaborators

• National Cancer Institute (NCI)

  collaborator NIH

• City of Hope Medical Center

  lead OTHER

Principal Investigators

• Jessica Cheng · City of Hope Medical Center

Study Design

Allocation

NA

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-11-13

Primary Completion

2027-11-26

Completion

2027-11-26

Countries

• United States

Study Locations