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Predicting HFNC Failure in Acute Hypoxemic Respiratory Failure Using Metabolomics and Clinical Data

NCT07607080 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2026-05-26

No results posted yet for this study

Summary

The goal of this observational study is to determine whether metabolomic profiles combined with clinical data can predict high-flow nasal cannula (HFNC) failure and help optimize respiratory support in adult patients with acute hypoxemic respiratory failure (AHRF). The main questions it aims to answer are:

Can metabolomic biomarkers identify patients at higher risk of HFNC failure? Does combining metabolomic and clinical data improve the prediction of respiratory support escalation and clinical outcomes?

Participants will:

Receive standard HFNC treatment according to clinical practice. Undergo collection of clinical, physiological, and laboratory data. Provide blood samples for metabolomic analysis during respiratory support.

Conditions

  • Acute Hypoxemic Respiratory Failure

Sponsors & Collaborators

  • Instituto de Salud Carlos III

    collaborator OTHER_GOV

  • Fundació La Marató de TV3

    collaborator OTHER

  • Hospital Universitari de Bellvitge

    collaborator OTHER

  • Hospital Universitari Joan XXIII de Tarragona.

    collaborator OTHER

  • Parc Taulí Hospital Universitari

    collaborator OTHER

  • Institute for Bioengineering of Catalonia

    collaborator OTHER

  • Hospital del Mar Research Institute (IMIM)

    lead OTHER

Principal Investigators

  • Francisco José Parrilla-Gómez, MD, Phd · Hospital del Mar

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-27
Primary Completion
2029-05-31
Completion
2029-05-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07607080 on ClinicalTrials.gov