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Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain

NCT07598994 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-05-20

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the effectiveness and safety of topical capsaicin cream and topical diclofenac gel in women with chronic temporomandibular joint-related pain. The main questions it aims to answer are:

* Does topical capsaicin reduce pain intensity more effectively than topical diclofenac?
* Do the treatments improve jaw function, pressure pain threshold, and neuropathic pain symptoms?

Researchers will compare topical capsaicin cream with topical diclofenac gel to evaluate differences in pain relief and functional improvement.

Participants will:

* Apply the assigned topical medication four times daily for 7 days
* Attend clinical examinations and pain assessments at baseline, Day 8, and Month 1
* Complete pain-related questionnaires and functional jaw measurements during follow-up visits

Conditions

  • Temporomandibular Disorders (TMD)
  • Temporomandibular Pain

Interventions

DRUG

Diclofenac 1% Topical

Topical diclofenac diethylammonium gel applied four times daily over the temporomandibular joint region for 7 days.

DRUG

Capsaicin Topical Cream

Topical capsaicin cream applied four times daily over the temporomandibular joint region for 7 days.

Sponsors & Collaborators

  • The Scientific and Technological Research Council of Turkey

    collaborator OTHER

  • Istanbul University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-01
Primary Completion
2026-04-05
Completion
2026-04-05

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07598994 on ClinicalTrials.gov