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Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness

NCT07594249 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 98

Last updated 2026-05-18

No results posted yet for this study

Summary

This study aims to determine whether shear wave elastography (SWE), a non-invasive ultrasound technique that measures nerve stiffness, can help detect ICU-acquired weakness (ICU-AW) early in critically ill patients. Adults receiving mechanical ventilation in the ICU will undergo ultrasound examinations of the median and tibial nerves on Days 1, 4, and 7. The study will evaluate whether early changes in nerve elasticity can predict ICU-AW, which is usually diagnosed later using a muscle strength score that requires patient cooperation.

Conditions

  • ICU-acquired Weakness
  • Critical Illness Polyneuropathy
  • Critical Illness Myopathy

Interventions

DIAGNOSTIC_TEST

Nerve Ultrasound with Shear Wave Elastography

Patients will undergo non-invasive ultrasound examinations of the median nerve and tibial nerve at the bedside on days 1, 4, and 7. The examination includes Shear Wave Elastography (SWE) to quantify nerve stiffness (elasticity) and B-mode imaging to measure nerve cross-sectional area (CSA). This is a purely observational procedure and does not alter patient management.

Sponsors & Collaborators

  • First Affiliated Hospital of Wannan Medical College

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07594249 on ClinicalTrials.gov