Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)

Summary

The NEPHRO-IBD study is a multicenter prospective observational study designed to evaluate the prevalence of renal dysfunction and renal complications in adult patients with inflammatory bowel disease (IBD) compared with individuals from the general population. Although extraintestinal manifestations are common in IBD, renal involvement remains relatively underrecognized and insufficiently studied.

The study will recruit approximately 6,000 participants, including 3,000 patients with confirmed IBD (Crohn's disease or ulcerative colitis) and 3,000 individuals without IBD serving as a control group. Participants will undergo routine clinical assessment, including laboratory tests, urinalysis with measurement of the albumin-to-creatinine ratio (ACR), and imaging evaluation of the kidneys and urinary tract. Disease activity in patients with IBD will be assessed using validated clinical indices.

The study will also evaluate the relationship between renal dysfunction and disease activity, medications used in IBD treatment, and comorbidities. The results of this study are expected to improve the understanding of renal complications in patients with IBD and support earlier identification and management of kidney disease in this population.

Conditions

• IBD and Renal Involement
• Chronic Kidney Disease
• Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)

Interventions

DIAGNOSTIC_TEST

Prospective assessment of the prevalence of kidney disease and/or renal complications in patients with IBD/the general population based on routine laboratory test and abdominal ultrasound.

No experimental intervention is performed. Participants undergo routine clinical evaluation, laboratory testing, urinalysis including albumin-to-creatinine ratio (ACR), and abdominal ultrasound as part of observational data collection.

Sponsors & Collaborators

• Poznan University of Medical Sciences

  collaborator OTHER

• Nicolaus Copernicus university Collegium Medicum, Bydgoszcz, Poland

  collaborator UNKNOWN

• Medical University of Lodz

  collaborator OTHER

• Jagiellonian University

  collaborator OTHER

• Medical University of Silesia

  collaborator OTHER

• Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji

  lead OTHER_GOV

Principal Investigators

• Grażyna Rydzewska, Professor · National Medical Institute of the Ministry of the Interior and Administration, Clinic of Gastroenterology and Internal Diseases.

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-11-20

Primary Completion

2026-11-30

Completion

2026-12-30

Countries

• Poland

Study Locations