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Identification of MPN-specific Antigens and Anti-MPN TCRs in Myeloproliferative Neoplasm

NCT07590986 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2026-05-15

No results posted yet for this study

Summary

The goal of this observational study is to learn how the immune system responds to myeloproliferative neoplasms (MPN) in adults with known or suspected MPN. Researchers also want to identify immune cells that could help develop future immune-based treatments for MPN.

The main questions it aims to answer are:

* Are there T cells in the bone marrow that can recognize MPN cells?
* Which targets (antigens) on MPN cells are recognized by these immune cells?
* Can researchers identify T cell receptors (TCRs) that may be used in future TCR-based therapies?

Researchers will study samples from adults with polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), post-PMF, or unclassifiable MPN. Samples from healthy donors without blood disorders will also be included for comparison.

By providing blood and bone marrow samples, participants will:

* Allow researchers to study immune cells and genetic material from these samples
* Allow researchers to perform laboratory tests to study how immune cells recognize MPN cells

Researchers will use laboratory methods such as genetic sequencing, cell analysis, and cell culture experiments to better understand immune responses in MPN.

Participants will not receive direct medical benefit from this study. The results may help researchers better understand MPN and support the future development of immune-based therapies.

Conditions

  • Myeloproliferative Neoplasm (MPN)
  • Polycytemia Vera
  • Essential Thrombocythemia (ET)
  • Primary Myelofibrosis (PMF)

Sponsors & Collaborators

  • Université Catholique de Louvain

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-31
Primary Completion
2036-12-31
Completion
2037-01-31

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07590986 on ClinicalTrials.gov