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Validation of the PRST Score Against Bispectral Index

NCT07590388 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 183

Last updated 2026-05-15

No results posted yet for this study

Summary

The goal of this randomized controlled trial is to evaluate whether the PRST (Evans) score is a valid method for monitoring the depth of general anesthesia in adult surgical patients. It will also assess whether combining the PRST score with Bispectral Index (BIS) monitoring improves anesthetic depth assessment compared with PRST-guided monitoring alone.

The main questions it aims to answer are:

1. Does the PRST score correlate with BIS values during general anesthesia?
2. Does visible BIS-guided monitoring improve anesthetic depth assessment compared with PRST-guided monitoring alone?

Researchers will compare patients managed using PRST-guided monitoring alone with patients managed using PRST plus visible BIS-guided monitoring.

Participants will:

1. Undergo elective surgery under general anesthesia
2. Receive intraoperative anesthetic depth monitoring using PRST score alone or PRST combined with BIS monitoring
3. Have PRST score, BIS, heart rate, and blood pressure recorded at predefined intraoperative timepoints
4. Complete a postoperative interview assessing recall, dreaming, and anesthesia-related discomfort

Conditions

  • Elective Surgeries
  • General Anesthesia
  • BIS

Interventions

DEVICE

PRST Monitoring

Clinical anesthetic depth monitoring using PRST score assessment without visible BIS-guided titration.

DEVICE

PRST + BIS Monitoring

Clinical anesthetic depth monitoring using PRST score combined with visible BIS-guided anesthetic titration targeting BIS 40-60.

Sponsors & Collaborators

  • Gadjah Mada University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-26
Primary Completion
2026-01-05
Completion
2026-01-05

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07590388 on ClinicalTrials.gov