A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma
NCT07589257 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2026-05-15
Summary
To Evaluate the Preliminary Efficacy and Safety/Tolerability of VRT106 Combined with Radiotherapy in Adult Patients with DMG/DIPG
Conditions
- Diffuse Midline Glioma, H3 K27M-Mutant
- Diffuse Intrinsic Pontine Glioma
Interventions
- DRUG
-
VRT106 for injection
VRT106, iv
Sponsors & Collaborators
-
Guangzhou Virotech Pharmaceutical Co., Ltd.
lead INDUSTRY
Principal Investigators
-
Yuanyuan Chen · Sun Yat-Sen University Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-05-07
- Primary Completion
- 2028-06-30
- Completion
- 2028-12-31
Countries
- China
Study Locations
More Related Trials
-
A Study to Evaluate the Safety, Tolerance and Initial Efficacy of EGFRvIII CAR-T on Glioblastoma
NCT05802693 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
G207 Followed by Radiation Therapy in Malignant Glioma
NCT00157703 ·Status: COMPLETED ·Phase: PHASE1
-
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
NCT03180502 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial
NCT06215495 ·Status: RECRUITING ·Phase: NA
-
A Phase II Study to Treat Advanced Malignant Glioma
NCT00427440 ·Status: COMPLETED ·Phase: PHASE2
-
GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma
NCT07301268 ·Status: RECRUITING ·Phase: PHASE2
-
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases
NCT01644591 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Neurocognitive Decline in Patients With Brain Metastases
NCT03508752 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection
NCT06018363 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Phase II Exploratory Study of Sequential Triple Therapy (Temozolomide/Anlotinib/Bemarituzumab) in Combination With Concurrent Radiotherapy With Temozolomide and Anlotinib for the Maintenance Treatment of Diffuse Midline Gliomas in Children
NCT07020052 ·Status: NOT_YET_RECRUITING
-
WP1066 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
NCT05879250 ·Status: RECRUITING ·Phase: PHASE2
-
The Efficacy and Safety of Low-dose Radiotherapy Combined With Sintilimab and Temozolomide in Recurrent Glioblastoma
NCT06220552 ·Status: RECRUITING ·Phase: PHASE2
-
DLL3 CAR-T Therapy Targeting Brain Tumors
NCT07180927 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of 177Lu-PSMA-617 in People With Gliomas
NCT07223034 ·Status: RECRUITING ·Phase: PHASE1
-
Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma
NCT06831773 ·Status: RECRUITING ·Phase: NA
-
SMART Trial: Cognitive Sparing Brain Radiotherapy for Multiple Brain Metastases
NCT07505979 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
NCT04427384 ·Status: RECRUITING
-
D2C7-IT With Atezolizumab for Recurrent Gliomas
NCT04160494 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Combination of PVSRIPO and Atezolizumab for Adults With Recurrent Malignant Glioma
NCT03973879 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
A Study of Apatinib in Recurrent or Recurrent High-grade Glioma
NCT03390062 ·Status: UNKNOWN ·Phase: PHASE2
-
INTRAGO-Intraoperative Radiotherapy for Glioblastoma - a Phase I/II Study
NCT02104882 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
TH-CAR-027 for Grade 4 Gliomas
NCT07384390 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma
NCT06910306 ·Status: RECRUITING ·Phase: NA
-
Open-Label Study of I-131-CLR1404 in Subjects With Recurrent Glioma
NCT01778088 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma
NCT02887040 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3