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Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in Induction of Ovulation

NCT07589075 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 500

Last updated 2026-05-15

No results posted yet for this study

Summary

The aim of the study is to assess the efficacy of adjuvant therapy dapagliflozin, metformin as monotherapy and combination of both in comparison to control group in induction of ovulation with letrozole in women PCOS, focusing specifically on rates of ovulation and pregnancy.

Conditions

  • Induction of Ovulation

Interventions

DRUG

Metformin 1000 mg

will take Metformin 1000 mg once daily with a main meal and started one month before initiation of the first cycle of induction.

DRUG

Dapagliflozin 10 mg

will take Dapagliflozin 10mg once daily with a main meal and started one month before initiation of the first cycle of induction.

DRUG

Combined Dapagliflozin-Metformin 5/1000mg

will take Combined Dapagliflozin-Metformin 5/1000mg once daily with a main meal and started one month before initiation of the first cycle of induction.

DRUG

Letrozole 2.5Mg Tablet

will take letrozole 2.5mg twice daily from the third day of the cycle for 5 days.

Sponsors & Collaborators

  • Beni-Suef University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-20
Primary Completion
2024-07-01
Completion
2025-10-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07589075 on ClinicalTrials.gov