Beta-3 Enhanced Autonomic Therapy for POTS
NCT07585513 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2026-05-13
Summary
The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.
Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS)
Interventions
- DRUG
-
Mirabegron
This is a randomized placebo controlled double blind trial comparing mirabegron with placebo in treating POTS
- DRUG
-
Matching placebo
Sponsors & Collaborators
-
Cedars-Sinai Medical Center
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-05-31
- Primary Completion
- 2028-05-31
- Completion
- 2028-05-31
- FDA Drug
- Yes
More Related Trials
-
Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm
NCT02296190 ·Status: COMPLETED ·Phase: PHASE2
-
JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart
NCT06701669 ·Status: RECRUITING ·Phase: PHASE2
-
Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasE
NCT01827059 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy of Ventavis Used in Real-life Setting.
NCT01355380 ·Status: COMPLETED
-
Ambrisentan in Patients With Porto-pulmonary Hypertension A Multicenter Open Label Trial
NCT01224210 ·Status: COMPLETED ·Phase: PHASE3
-
Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension
NCT00313222 ·Status: COMPLETED ·Phase: PHASE3
-
Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
NCT00319111 ·Status: COMPLETED ·Phase: PHASE3
-
Characterization and Detection of Prolonged Endothelin Receptors Antagonists Administration
NCT01352065 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Placebo Controlled Trial of Bosentan in Scleroderma Patients
NCT00377455 ·Status: TERMINATED ·Phase: PHASE2
-
Single and Multiple Ascending Doses Clinical Pharmacology Study With KAR5585
NCT02746237 ·Status: COMPLETED ·Phase: PHASE1
-
Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil
NCT03399604 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
NCT04691154 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Bosentan for Severe Mitral Valve Dysfunction
NCT01270750 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Evaluation of Inhaled Iloprost Effects Using the Breelib Nebulizer, on Clinical Outcomes and Physical Activity of Patients With Advanced Pulmonary Arterial Hypertension
NCT03293407 ·Status: COMPLETED
-
To Evaluate The Safety and Initial Efficacy of STSA-1002 Injection in Patients With Acute Respiratory Distress Syndrome
NCT06038916 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension
NCT03657095 ·Status: TERMINATED ·Phase: PHASE3
-
Safety Follow-up Study of Inhaled Iloprost in Patients With Pulmonary Hypertension
NCT00185315 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate the Efficacy and Safety of Eplerenone in the Treatment of Hypertension in Children.
NCT00147589 ·Status: COMPLETED ·Phase: PHASE3
-
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)
NCT00303459 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Bisoprolol on Progression of Aortic Stenosis
NCT01579058 ·Status: TERMINATED ·Phase: PHASE4
-
Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil
NCT03992755 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
NCT00091715 ·Status: COMPLETED ·Phase: PHASE3
-
Early Therapy of Pulmonary Arterial Hypertension
NCT00909337 ·Status: COMPLETED ·Phase: NA
-
A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
NCT07285655 ·Status: RECRUITING ·Phase: PHASE3
-
Acute Exposure of Simulated Hypoxia on ECG and Non-invasive Blood Pressure
NCT03581851 ·Status: COMPLETED ·Phase: NA