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International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

NCT07576036 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 800

Last updated 2026-05-08

No results posted yet for this study

Summary

Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l. Data on patient demographics, presenting symptoms, vital signs, laboratory findings, treatment given, sodium correction rates, presence of risk factors for osmotic demyelination syndrome (ODS) and outcomes including suspected and MRI-confirmed ODS, in-hospital death, and imaging confirmation of cerebral edema

Conditions

  • Hyponatremia Symptomatic
  • Osmotic Demyelination Syndrome
  • Cerebral Edema

Interventions

DRUG

Hypertonic 3% saline

Rapid Correction of hyponatremia

Sponsors & Collaborators

  • University of Pittsburgh Medical Center

    collaborator OTHER

  • Rochester General Hospital

    lead OTHER

Principal Investigators

  • Richard H Sterns, MD · University of Rochester

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-01
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07576036 on ClinicalTrials.gov