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Transcranial Magnetic Stimulation as a Treatment for Postpartum Obsessive Compulsive Disorder

NCT07571187 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-05-06

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if accelerated transcranial magnetic stimulation (TMS) is a feasible treatment for obsessive compulsive disorder that worsens or starts within 12 months of childbirth. The main questions it aims to answer are:

Is TMS a tolerable and acceptable treatment for postpartum women with OCD?

Does TMS improve OCD symptoms in postpartum women?

Does TMS change connectivity between areas of the brain involved in OCD?

Participants will:

1. Receive 50 sessions of a type of TMS called continuous theta burst stimulation (cTBS) over the course of two weeks.
2. Complete clinical assessments before and after TMS, as well as at 1 and 3 months post-treatment
3. Undergo functional magnetic resonance imaging (fMRI) of the brain before and after TMS

Conditions

  • Postpartum Obsessive Compulsive Disorder

Interventions

DEVICE

Accelerated Continuous Theta Burst Stimulation (cTBS)

Participants will receive 50 sessions of cTBS administered as 5 sessions per day over 10 days to the right orbitofrontal cortex. Each session will be 1800 pulses total.

Sponsors & Collaborators

  • Butler Hospital

    lead OTHER

Principal Investigators

  • Meghan J. Kulak, MD · Butler Hospital

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2028-01-31
Completion
2028-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07571187 on ClinicalTrials.gov