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Comparing Three Rescue Bowel Preparation Regimens for Colonoscopy After Failed Cleansing

NCT07557173 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 220

Last updated 2026-05-14

No results posted yet for this study

Summary

The goal of this clinical trial is to learn which rescue bowel preparation works best for adults who need a repeat colonoscopy after a previous bowel preparation did not clean the bowel well enough. The study will also look at how satisfied participants are with each preparation. The main questions it aims to answer are:

* Which bowel preparation helps more participants achieve adequate bowel cleansing before repeat colonoscopy?
* Which bowel preparation leads to better cleansing in different parts of the colon?
* Which bowel preparation is better tolerated by participants?

Researchers will compare 3 rescue bowel preparation regimens to see which one works best for repeat colonoscopy after a previous cleansing failure.

Participants will:

* be randomly assigned to 1 of 3 bowel preparation regimens
* take one of the following regimens before repeat colonoscopy:
* 4 liters of polyethylene glycol (PEG) plus 12 milligrams of bisacodyl
* 1 liter of PEG plus ascorbic acid plus 10 milligrams of bisacodyl
* 2 liters of PEG plus extra PEG taken over the 3 days before colonoscopy
* undergo repeat colonoscopy
* rate their satisfaction with the bowel preparation

Conditions

  • Bowel Cleansing for Colonoscopy
  • Inadequate Bowel Preparation

Interventions

DRUG

Drug

4 liters of polyethylene glycol plus bisacodyl 12 mg administered as rescue bowel preparation before repeat colonoscopy.

DRUG

Drug

1 liter of polyethylene glycol plus ascorbic acid and bisacodyl 10 mg administered as rescue bowel preparation before repeat colonoscopy.

DRUG

Drug

2 liters of polyethylene glycol plus additional polyethylene glycol administered during the 3 days before repeat colonoscopy.

Sponsors & Collaborators

  • Ospedale San Pio

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-02
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07557173 on ClinicalTrials.gov