Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers

Summary

This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers. Lung cancer, the leading cause of cancer death, is overwhelmingly caused by exposure to cigarette smoke. Research suggests that daily activity reduces lung cancer risk in current and former smokers. However, current and former smokers are generally not active and new approaches to improve lung health are needed. During the home-based RMT program, participants use a handheld device to complete breathing exercise sessions consisting of breathing in and out against adjustable resistance. During the home-based AE program, participants complete aerobic exercises using a stationary bike working at a moderate workload against adjustable resistance. The home-based RMT and AE programs may be effective ways to strengthen the breathing muscles, which may improve lung health in current and former cigarette smokers.

Conditions

• Lung Carcinoma

Interventions

PROCEDURE

Accelerometry

Ancillary studies

OTHER

Aerobic Exercise

Complete tailored intensity AE cycling sessions

PROCEDURE

Biospecimen Collection

Undergo blood, nasal swab, exhaled breath, and urine sample collection

OTHER

Educational Intervention

Receive AE and RMT education

OTHER

Electronic Health Record Review

Ancillary studies

OTHER

Physical Performance Testing

Ancillary studies

PROCEDURE

Respiratory Muscle Training

Complete RMT sessions

OTHER

Supportive Care

Receive virtually supervised session/call

OTHER

Survey Administration

Ancillary studies

Sponsors & Collaborators

• Roswell Park Cancer Institute

  lead OTHER

Principal Investigators

• Andrew D Ray · Roswell Park Cancer Institute

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-05-01

Primary Completion

2029-05-01

Completion

2029-05-01

Countries

• United States

Study Locations