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Hemodynamic Effects of Lithotomy Position in Surgical Patients (PH-LITHO)

NCT07549152 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-05-14

No results posted yet for this study

Summary

Anesthesia-induced hypotension is a common occurrence in elderly hypertensive patients and is closely associated with increased postoperative morbidity

* This study aims to investigate whether the lithotomy position, a non-pharmacological and cost-free approach, can reduce the incidence of post-induction hypotension (PIH) in this high-risk population by increasing venous return

Sixty patients aged 65-80 with a history of hypertension were randomly assigned to either the Supine Group (Group S) or the Lithotomy Group (Group L)

* In Group L, patients were placed in the lithotomy position 120 seconds before the start of anesthesia induction
* Blood pressure was monitored every minute for the first five minutes following induction
* The study evaluates whether this simple positioning strategy can maintain hemodynamic stability, reduce the drop in mean arterial pressure, and decrease the overall need for vasopressor medications like ephedrine

Conditions

  • Post-induction Hypotension (PIH)
  • Hypertension (HTN)
  • Geriatric Anesthesia

Interventions

OTHER

Pre-induction Lithotomy Position

Patients are moved to the lithotomy position 120 seconds prior to the start of anesthesia induction to increase venous return * Following this 120-second interval in the lithotomy position, anesthesia is induced with intravenous midazolam (0.05 mg/kg), fentanyl (1 µg/kg), and thiopental (3-5 mg/kg) * All inductions are performed at a constant rate over 120 seconds * Post-induction hypotension (defined as MAP \< 65 mmHg or \>20% drop from baseline) is treated with 5 mg of intravenous ephedrine

OTHER

Standard Supine Position

Patients remain in the standard supine position for a 3-minute rest period before induction begins * General anesthesia is induced using the same protocol as the experimental group: intravenous midazolam (0.05 mg/kg), fentanyl (1 µg/kg), and thiopental (3-5 mg/kg) administered over a period of 120 seconds * Hypotension (defined as MAP \< 65 mmHg or \>20% drop from baseline) is managed with 5 mg of intravenous ephedrine as rescue therapy

Sponsors & Collaborators

  • Trabzon Karadeniz Teknik Universitesi

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-03-01
Primary Completion
2022-01-31
Completion
2022-01-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07549152 on ClinicalTrials.gov