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Effect of a Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients.

NCT07544186 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2026-04-22

No results posted yet for this study

Summary

This study aims to evaluate the impact of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical functionality in recovered COVID-19 patients.

The primary research question is: What is the effect of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical capacity in recovered COVID-19 patients, compared to those receiving conventional medical management? A nutritional treatment combined with L-citrulline supplementation (intervention group) will be compared against conventional treatment alone (control group). Both groups will undergo pulmonary rehabilitation for a 3-month follow-up.

Subjects assigned to the intervention group will be required to:

* Take 4 g of L-citrulline daily for 3 months.
* Attend an interim session at 1.5 months for review of the nutritional treatment and supplementation.
* Keep a record of each supplement intake.

Conditions

  • Supplemental Nutrition Assistance Program Education
  • Post COVID Syndrome
  • Endothelial Function

Interventions

DIETARY_SUPPLEMENT

L-citrulline supplementation

Subjects allocated to the intervention group receive 4 grams of L-citrulline supplementation daily, combined with nutritional therapy, over a 3-month period.

Sponsors & Collaborators

  • Instituto Nacional de Enfermedades Respiratorias

    lead OTHER_GOV

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-09
Primary Completion
2022-11-11
Completion
2023-08-10

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07544186 on ClinicalTrials.gov