MedTrace Logo

Biologic Augmentation of TMJ Arthroscopy Using BMAC

NCT07536399 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-07-29

No results posted yet for this study

Summary

The goal of this clinical trial is to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections in patients with pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment. The main question it aims to answer:

Does BMAC injection reduce the amount of inflammation and structural damage in the TMJ? Researchers will compare BMAC injection to corticosteroid injections see if BMAC injection helps .

Participants will :

* Be randomized to receive either BMAC or CS injection during TMJ arthroscopy
* Visit the clinic for 3 follow up visits over 6 months and answer questionnaires
* have 2 MRIs of their jaw

Conditions

  • TMJ - Oral &Maxillofacial Surgery
  • Oral and Maxillofacial Conditions
  • TMJ Pain
  • TMJ Arthralgia

Interventions

BIOLOGICAL

Bone Marrow Aspirate Concentrate

Single dose injection of bone marrow fluid from the participant's anterior iliac crest (hip) into the TMJ area during arthroscopy.

DRUG

Corticosteroid (CS)

Single dose injection of cortiosteroid into the TMJ area during arthroscopy.

Sponsors & Collaborators

  • Oral and Maxillofacial Surgery Foundation, Rosemont ,Illinois

    collaborator UNKNOWN

  • Weill Medical College of Cornell University

    lead OTHER

Principal Investigators

  • Gwendolyn Reeve, DMD · Weill Medical College of Cornell University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2027-12-31
Completion
2028-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07536399 on ClinicalTrials.gov