A Phase I Clinical Study of HLX3902 in Patients With mCRPC and Other Advanced Tumours
NCT07533708 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 48
Last updated 2026-04-16
Summary
This study is an open-label first-in-human phase I clinical study to evaluate the safety, tolerability, and pharmacokinetic characteristics of HLX3902 in patients with mCRPC and other advanced solid tumours.
Conditions
- mCRPC or Advanced/Metastatic Solid Tumors
Interventions
- DRUG
-
HLX3902
HLX3902 will be administered as an intravenous (IV) infusion.
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-05-25
- Primary Completion
- 2027-06-29
- Completion
- 2028-05-24
More Related Trials
-
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of HLX35 in Combination With HLX10 in Patients With Advanced or Metastatic Solid Tumors
NCT05442996 ·Status: UNKNOWN ·Phase: PHASE1
-
The Safety,Efficacy of Anti-EGFR Humanized Monoclonal Antibody Combined With Chemotherapy in Advanced Solid Tumors.
NCT03577704 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HLX3901 in Patients With Advanced SCLC or NEC
NCT07416695 ·Status: RECRUITING ·Phase: PHASE1
-
A Phase I Study to Evaluate the Safety, Tolerability, and PK of HLX43 in Advanced/Metastatic Solid Tumors
NCT06115642 ·Status: RECRUITING ·Phase: PHASE1
-
HLX301 (TIGIT×PDL1 Bispecific) in Patients With Locally Advanced or Metastatic Solid Tumors
NCT05102214 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of HX008 for the Treatment of Patients With Metastatic Triple Negative Breast Cancer
NCT04750382 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Anti-PD-1 Antibody (HLX10) in Combination With Avastin Biosimilar (HLX04) in Patients With Advanced Solid Tumors
NCT03757936 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study to Evaluate the Efficacy and Safety of HLX07 in nsqNSCLC Patients With High EGFR Expression
NCT05215925 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase I Clinical Study of HLX53 in Advanced/Metastatic Solid Tumors
NCT05394168 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Phase II Clinical Study to Evaluate HLX43 in Patients With Locally Advanced or Metastatic HCC Failed or Intolerance to Standard Therapy
NCT06742892 ·Status: RECRUITING ·Phase: PHASE2
-
Phase 1 Study of HLX10, a Monoclonal Antibody Targeting Programmed Death-1 (PD-1) in Patients With Advanced Solid Tumors
NCT03468751 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of HLX42 in Advanced/Metastatic Solid Tumors
NCT06210815 ·Status: RECRUITING ·Phase: PHASE1
-
HX009+ IN10018 With or Without Standard Chemotherapy for Advanced Solid Tumours
NCT06708663 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of HLX26 and HLX10 in Patients With Advanced/Metastatic Solid Tumor
NCT05400265 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study of HLX20, a Human Monoclonal Antibody Targeting PD-L1Protein in Patients With Advanced Solid Tumors
NCT03588650 ·Status: COMPLETED ·Phase: PHASE1
-
Recombinant Human Anti-PD-1 Monoclonal Antibody HX008 Injection for the Treatment of Advanced Solid Tumors
NCT03704246 ·Status: UNKNOWN ·Phase: PHASE2
-
A Randomized, Single Intravenous Dose, Parallel Phase I Clinical Study to Compare the Pharmacokinetic Characteristics, Safety, and Immunogenicity of HLX05 Vs. Erbitux® (Cetuximab) in Healthy Adult Male Chinese Subjects
NCT06309043 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Evaluate Safety, Tolerability and Pharmacokinetics of HLX22 in Patients With Advanced Solid Tumors Overexpressing HER2
NCT03916094 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase Ib/II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Patients With Advanced/Metastatic Solid Tumors
NCT06848699 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of MHB048C in Patients With Advanced Solid Tumors
NCT07192120 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Safety and Pharmacokinetic Study Between HLX02 and Herceptin®(US-licensed and EU-approved) in Healthy Chinese Male Subjects
NCT04670796 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance to Standard Therapy
NCT06769113 ·Status: RECRUITING ·Phase: PHASE2
-
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
NCT07085091 ·Status: RECRUITING ·Phase: PHASE1
-
Recombinant Humanized Anti-CD47 / PD-1 Bifunctional Antibody HX009 Injection in the Treatment of Advanced Solid Tumors
NCT04886271 ·Status: COMPLETED ·Phase: PHASE2
-
Phase I PK Comparison of HLX05 vs. Erbitux® in Healthy Chinese Males: Safety, Immunogenicity, and Pharmacokinetics
NCT06980454 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1