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Impact of Platelet Concentration in PRP on TMJ Subluxation

NCT07532798 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-04-16

No results posted yet for this study

Summary

This study is about a treatment for a jaw condition called temporomandibular joint (TMJ) subluxation. In this condition, the jaw can move too far forward during mouth opening, which may cause repeated jaw locking and problems with normal function.

The treatment being studied is platelet-rich plasma (PRP) injections. PRP is made from a person's own blood and may help improve joint stability and reduce symptoms.

In this study, 40 adults with TMJ subluxation were randomly assigned to receive PRP with either a lower or higher platelet concentration. Each participant received 2 injections, given 2 weeks apart.

The study measured jaw pain, how often locking happened, mouth opening, and joint clicking before treatment, after 6 months, and after 5 years.

The goal of this study is to find out whether the amount of platelets in PRP changes how well this treatment works.

Conditions

  • Temporomandibular Disorders (TMDs)

Interventions

PROCEDURE

Low Platelet Concentration PRP (L-PRP)

Intra-articular and pericapsular injection of platelet-rich plasma prepared with Low platelet concentration..

PROCEDURE

High Platelet Concentration PRP (L-PRP)

Intra-articular and pericapsular injection of platelet-rich plasma prepared with high platelet concentration.

Sponsors & Collaborators

  • IBB University

    lead OTHER

Principal Investigators

  • Hamida Refai, PhD · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-04-01
Primary Completion
2017-01-01
Completion
2017-07-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07532798 on ClinicalTrials.gov