MedTrace Logo

Probiotic and Synbiotic Supplements in Hemodialysis Patients

NCT07531186 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-04-15

No results posted yet for this study

Summary

This single-center randomized controlled trial evaluated the effects of natural probiotic and synbiotic supplementation on clinical and biochemical characteristics in adults with end-stage renal disease receiving maintenance hemodialysis at the Urology and Nephrology Center, Mansoura University, Egypt. Participants were randomized into three groups (control, probiotic, and synbiotic), with supplementation given for 6 months in the intervention groups. The study assessed changes in uremic toxins (including p-cresyl sulfate) as the primary outcome, and cardiovascular parameters, quality of life, and cognitive function as secondary outcomes. The trial aimed to determine whether modulation of gut microbiota with probiotics or synbiotics can improve outcomes in hemodialysis patients

Conditions

  • End Stage Renal Disease (ESRD)
  • Kidney Failure, Chronic
  • Hemodialysis

Interventions

DIETARY_SUPPLEMENT

Natural Probiotic Supplement

Oral natural probiotic supplementation was administered in addition to standard maintenance hemodialysis care for 6 months.

DIETARY_SUPPLEMENT

Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)

Oral synbiotic supplementation (natural probiotic plus prebiotic fiber \[oat\]) was administered in addition to standard maintenance hemodialysis care for 6 months.

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2025-09-30
Completion
2025-10-05

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07531186 on ClinicalTrials.gov