Functional and Respiratory Predictors of Early Postoperative Outcomes

Summary

Functional status is a fundamental indicator reflecting a patient's ability to perform activities of daily living and is closely associated with early postoperative outcomes. Patients with low functional capacity are known to have an increased risk of postoperative complications, prolonged length of hospital stay, and higher mortality rates. Similarly, respiratory function plays a decisive role in the development of postoperative complications and influences early surgical outcomes. In the preoperative period, inadequate respiratory capacity and poor functional performance increase the risk of postoperative pulmonary complications and delayed recovery. Therefore, functional and respiratory assessments are regarded as integral components of the preoperative preparation process.

Early outcomes in patients undergoing colorectal cancer surgery are of critical importance in reducing mortality and morbidity. In this surgical population, advanced age, comorbidities, and diminished physical capacity may further increase the risk of postoperative complications. Accordingly, the evaluation of preoperative functional status and physiological reserve has gained increasing importance for risk stratification and perioperative management. However, studies examining the impact of functional status and respiratory parameters on early surgical outcomes in patients with colorectal cancer remain limited. Consequently, the available evidence is insufficient to establish a standardized assessment approach in clinical practice.

Moreover, objective evaluation of patients' functional and respiratory capacities in the preoperative period is essential for predicting surgical risk and planning individualized perioperative care. Determining the relationships between these parameters and early clinical outcomes may facilitate the identification of high-risk patients and contribute to the development of targeted strategies aimed at preventing postoperative complications. Findings obtained in this context are expected to provide a scientific basis for clinical decision-making and multidisciplinary patient management in individuals undergoing colorectal cancer surgery, thereby guiding clinical practice.

Conditions

• Colorectal Cancer
• Functional Status
• Respiratory Parameters
• Clinical Outcomes

Interventions

OTHER

Preoperative Assessments

Preoperative Assessments Sociodemographic and Clinical Characteristics Sociodemographic and clinical characteristics of the patients will be recorded. Respiratory Function Respiratory function will be measured using standard spirometric evaluation methods. Forced expiratory volume in one second (FEV₁), forced vital capacity (FVC), and peak expiratory flow (PEF) values will be recorded. Physical Activity Level Physical activity level will be assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Physical Performance Physical performance will be evaluated using the Short Physical Performance Battery (SPPB). The SPPB consists of the 4-meter gait speed test, the chair stand test, and the standing balance test. The total score will be calculated. Ultrasonography Diaphragmatic muscle thickness will be measured using ultrasonography. Handgrip Strength Right- and left-hand grip strength will be measured using a hand dynamometer.

OTHER

Postoperative Assessments (Daily from Postoperative Day 1 Until Discharge)

Pain severity will be assessed using the McGill-Melzack Pain Questionnaire. The total pain score will be recorded. Patient Mobility Patient mobility will be assessed using the Patient Mobility Scale. Quality of Recovery Postoperative recovery quality will be evaluated using the Quality of Recovery-40 (QoR-40) questionnaire. The total score will be recorded. Daily Analgesic Consumption The amount of daily analgesic use will be recorded. Daily Flatus and Defecation The frequency and timing of daily flatus and bowel movements will be recorded. Mobilization Daily mobilization duration, frequency, and mobilization distance (in meters) will be recorded.

Sponsors & Collaborators

• Inonu University

  collaborator OTHER

• Müşerref Ebru YALÇIN

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-03-01

Primary Completion

2026-08-25

Completion

2027-02-25

Countries

• Turkey (Türkiye)

Study Locations