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Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use

NCT07527338 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 58

Last updated 2026-05-08

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if cannabidiol helps to improve sleep and decrease alcohol use. It will also learn about the safety of cannabidiol. The main questions it aims to answer are:

Does 4 weeks of nightly cannabdiol use:

1. improve sleep quality and time spent in REM sleep?
2. decrease alcohol use and alcohol craving?
3. pose any safety risks?

Researchers will compare cannabidiol to a placebo (a look-alike substance that contains no drug).

Participants will:

Take cannabidiol every night for 4 weeks Visit the clinic once at the beginning and once at the end of the study Wear an activity monitoring watch while in the study Complete an at-home sleep test both at the beginning and the end of the study Check in once a week with researchers via video conference

Conditions

  • Sleep
  • Alcohol Misuse

Interventions

DRUG

Cannabidiol

300mg broad spectrum hemp extract in 50mg softgels

DRUG

Placebo

Taste and appearance matched softgel with hemp seed oil, glycerin, and gelatin

Sponsors & Collaborators

  • University of Colorado, Boulder

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-31
Primary Completion
2030-12-01
Completion
2031-02-01
FDA Drug
Yes

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Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07527338 on ClinicalTrials.gov