Trial Outcomes & Findings for Single-Session Extraoral PBM After Third Molar Extraction (NCT NCT07522918)
NCT ID: NCT07522918
Last Updated: 2026-06-09
Results Overview
Postoperative pain assessed using a 100-mm visual analog scale (VAS; 0 = no pain, 100 = worst imaginable pain)
COMPLETED
NA
70 participants
Postoperative Day 2, and Postoperative Day 7.
2026-06-09
Participant Flow
Participants were recruited from the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Necmettin Erbakan University, between February 2025 and January 2026.
Potential participants were screened based on clinical and radiographic criteria (mesioangular impacted mandibular third molars, Pell-Gregory Class IB). A total of 70 eligible patients were randomized into two equal groups.
Participant milestones
| Measure |
Control Group
Participants underwent standardized surgical extraction and received a standard postoperative medication regimen without photobiomodulation therapy.
|
PBM Group
Participants received a single 10-minute session of extraoral dual-wavelength photobiomodulation (650 nm + 904 nm, 270 J) applied immediately after the surgical extraction.
|
|---|---|---|
|
Overall Study
STARTED
|
35
|
35
|
|
Overall Study
COMPLETED
|
35
|
35
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
PBM Group
n=35 Participants
Participants received a single 10-minute session of extraoral dual-wavelength photobiomodulation (650 nm + 904 nm, 270 J) applied immediately after the surgical extraction.
|
Control Group
n=35 Participants
Participants underwent standardized surgical extraction and received a standard postoperative medication regimen without photobiomodulation therapy.
|
Total
n=70 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
21.94 years
STANDARD_DEVIATION 2.83 • n=35 Participants
|
22.14 years
STANDARD_DEVIATION 2.4 • n=35 Participants
|
22.04 years
STANDARD_DEVIATION 2.61 • n=70 Participants
|
|
Sex: Female, Male
Female
|
22 Participants
n=35 Participants
|
20 Participants
n=35 Participants
|
42 Participants
n=70 Participants
|
|
Sex: Female, Male
Male
|
13 Participants
n=35 Participants
|
15 Participants
n=35 Participants
|
28 Participants
n=70 Participants
|
|
Race and Ethnicity Not Collected
|
—
|
—
|
0 Participants
Race and Ethnicity were not collected from any participant.
|
PRIMARY outcome
Timeframe: Postoperative Day 2, and Postoperative Day 7.Postoperative pain assessed using a 100-mm visual analog scale (VAS; 0 = no pain, 100 = worst imaginable pain)
Outcome measures
| Measure |
PBM Group
n=35 Participants
Participants received a single 10-minute session of extraoral dual-wavelength photobiomodulation (650 nm + 904 nm, 270 J) applied immediately after the surgical extraction.
|
Control Group
n=35 Participants
Participants underwent standardized surgical extraction and received a standard postoperative medication regimen without photobiomodulation therapy.
|
|---|---|---|
|
Postoperative Pain
Postoperative Day 2
|
20.34 mm (0-100 VAS)
Standard Deviation 24.38
|
41.43 mm (0-100 VAS)
Standard Deviation 25.15
|
|
Postoperative Pain
Postoperative Day 7
|
6.74 mm (0-100 VAS)
Standard Deviation 15.08
|
9.34 mm (0-100 VAS)
Standard Deviation 11.16
|
SECONDARY outcome
Timeframe: Preoperatively (baseline), Postoperative Day 2, and Postoperative Day 7.Facial edema quantified by the sum of distances between three anatomical reference points: tragus to labial commissure, gonion to lateral canthus, and gonion to labial commissure. Total facial distance measured in mm
Outcome measures
| Measure |
PBM Group
n=35 Participants
Participants received a single 10-minute session of extraoral dual-wavelength photobiomodulation (650 nm + 904 nm, 270 J) applied immediately after the surgical extraction.
|
Control Group
n=35 Participants
Participants underwent standardized surgical extraction and received a standard postoperative medication regimen without photobiomodulation therapy.
|
|---|---|---|
|
Postoperative Edema
Preoperative (Baseline)
|
284.00 mm
Standard Deviation 18.57
|
288.20 mm
Standard Deviation 20.31
|
|
Postoperative Edema
Postoperative Day 2
|
300.89 mm
Standard Deviation 19.46
|
306.83 mm
Standard Deviation 20.59
|
|
Postoperative Edema
Postoperative Day 7
|
290.40 mm
Standard Deviation 16.90
|
292.80 mm
Standard Deviation 20.94
|
SECONDARY outcome
Timeframe: Preoperatively (baseline), Postoperative Day 2, and Postoperative Day 7.Assessed by measuring the maximum interincisal distance (MID) between the incisal edges of the maxillary and mandibular central incisors during maximum active mouth opening.Maximum interincisal opening measured in mm using a digital caliper.
Outcome measures
| Measure |
PBM Group
n=35 Participants
Participants received a single 10-minute session of extraoral dual-wavelength photobiomodulation (650 nm + 904 nm, 270 J) applied immediately after the surgical extraction.
|
Control Group
n=35 Participants
Participants underwent standardized surgical extraction and received a standard postoperative medication regimen without photobiomodulation therapy.
|
|---|---|---|
|
Trismus
Preoperative (Baseline)
|
46.54 mm
Standard Deviation 5.32
|
45.91 mm
Standard Deviation 5.10
|
|
Trismus
Postoperative Day 2
|
32.14 mm
Standard Deviation 6.45
|
28.45 mm
Standard Deviation 7.12
|
|
Trismus
Postoperative Day 7
|
41.20 mm
Standard Deviation 5.80
|
39.15 mm
Standard Deviation 6.25
|
SECONDARY outcome
Timeframe: Postoperative Day 2 and Postoperative Day 7.Quality of life was assessed using a 100-mm Visual Analog Scale (VAS), where 0 represents the worst quality of life and 100 represents normal quality of life. Higher scores indicate a better quality of life
Outcome measures
| Measure |
PBM Group
n=35 Participants
Participants received a single 10-minute session of extraoral dual-wavelength photobiomodulation (650 nm + 904 nm, 270 J) applied immediately after the surgical extraction.
|
Control Group
n=35 Participants
Participants underwent standardized surgical extraction and received a standard postoperative medication regimen without photobiomodulation therapy.
|
|---|---|---|
|
Oral Health-Related Quality of Life (OHRQoL)
Postoperative Day 2
|
69.83 score on a scale (0-100)
Standard Deviation 25.87
|
50.51 score on a scale (0-100)
Standard Deviation 23.24
|
|
Oral Health-Related Quality of Life (OHRQoL)
Postoperative Day 7
|
92.34 score on a scale (0-100)
Standard Deviation 12.93
|
87.89 score on a scale (0-100)
Standard Deviation 15.40
|
Adverse Events
PBM Group
Control Group
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr Zeynep Asude Bozkır
Necmettin Erbakan University, Faculty of Dentistry
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place