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The Effects of Acute Erythropoietin on Hepcidin and Dietary Iron Absorption Following Military-relevant Exercise in Energy Deficit: Pilot Study

NCT07517562 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2026-04-08

No results posted yet for this study

Summary

Military personnel frequently experience declines in iron status during training and when in the field, which may compromise performance. The overall purpose of this study is to determine why the decline in iron status occurs and potential countermeasures. Participants will be given an acute dose of erythropoietin (EPO) or placebo and will complete a 90-minute load carriage exercise test. Prior to the main trial, this pilot study will determine the optimal approach to assess iron absorption following exercise (red blood cell incorporation or plasma isotope appearance), the percentage of iron incorporated into red blood cells with EPO compared to placebo, and the timing of the intervention.

Conditions

  • Iron Absorption

Interventions

OTHER

Exercise test

90-minute load carriage exercise test on a treadmill

Sponsors & Collaborators

  • Pennington Biomedical Research Center

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2025-12-31
Completion
2026-05-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07517562 on ClinicalTrials.gov