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Examining Olive Oil Extract on Knee Comfort and Function

NCT07514013 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 168

Last updated 2026-04-15

No results posted yet for this study

Summary

The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults?

The main procedures in the study include:

* Screening and informed consent
* Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks
* Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times
* Complete a Day 1 acute assessment and two simple functional movement tests at home as described below
* If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below.
* Collect saliva samples at home using a provided kit at designated timepoints
* Record any pain medications taken during the study or any side effects

Conditions

  • Healthy Adult Male
  • Healthy Adult Females
  • Joint Discomfort

Interventions

DIETARY_SUPPLEMENT

Olive Oil Extract

The investigational product is an olive oil extract dietary supplement formulated for oral consumption. The product is provided in capsule form and is intended for general wellness use, including support of joint comfort and function. Each capsule delivers a standardized amount of olive-derived bioactive compounds, including oleocanthal and oleacein.

DIETARY_SUPPLEMENT

Placebo

The comparator product is a matched placebo formulated from refined olive oil extract and is similar in appearance, taste, and packaging to the investigational product. The placebo is intended to serve as a control for study comparisons and does not contain the standardized olive-derived bioactive compounds present in the investigational product.

Sponsors & Collaborators

  • Alethios, Inc.

    collaborator INDUSTRY

  • Applied Food Sciences Inc.

    lead INDUSTRY

Principal Investigators

  • Chad Kerksick, PhD

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2026-10-01
Completion
2026-11-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07514013 on ClinicalTrials.gov