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Efficacy of Human UC-MSC-derived Exosomes and BM-MSC-derived Exosomes for Atrophic Acne Scar

NCT07510295 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2026-04-14

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if exosomes from human umbilical cord and bone marrow can improve atrophic acne scars when used after fractional CO₂ laser treatment in adults.

The main questions it aims to answer are:

* Do exosomes improve acne scars more than standard treatment alone?
* Are exosomes safe when used after laser treatment? Researchers will compare one side of the face treated with exosomes to the other side treated with a control solution (hyaluronic acid) to see if exosomes improve scar appearance and skin texture.

Participants will:

* Receive two sessions of fractional CO₂ laser treatment, 4 weeks apart
* Have exosomes applied to one side of the face and a control solution applied to the other side after each treatment
* Continue applying the assigned solution at home for 2 days after each session
* Attend follow-up visits to assess scar improvement, skin texture, healing time, and side effects Researchers will measure changes in acne scars using clinical scoring systems, skin imaging, and patient satisfaction. Safety will also be monitored by recording any side effects such as redness, swelling, or acne flare.

This study may help determine whether exosomes can improve the results of laser treatment for acne scars without increasing side effects

Conditions

  • Atrophic Acne Scars

Interventions

BIOLOGICAL

Exosomes derived from human umbilical cord and bone marrow mesenchymal stem cells

\- Topical application of exosomes derived from human umbilical cord and bone marrow mesenchymal stem cells applied immediately after fractional CO₂ laser treatment and continued for 2 days.

OTHER

Hyaluronic Acid (HA)

Topical application of hyaluronic acid solution used as a control following ablative fractional CO₂ laser treatment. The solution is applied immediately after each laser session and continued twice daily for 2 days.

Sponsors & Collaborators

  • Ngô Anh Tuấn

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-17
Primary Completion
2025-07-07
Completion
2025-07-07

Countries

  • Vietnam

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07510295 on ClinicalTrials.gov