A Study of Adaptive Radiotherapy of Head-neck Cancer Using Daily Replanning and Optimization of the Treatment Plan.
NCT07506902 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2026-04-02
Summary
Radiotherapy of head-neck cancer is associated with significant side effects. Using daily online adaptive radiotherapy to account for the changing anatomy, radiation to organs at risk can be lowered. We will investigate whether this is feasible and associated with a reduction in the risk of toxicity.
Conditions
- Head & Neck Squamous Cell Carcinoma
Interventions
- RADIATION
-
Daily online adaptive radiotherapy
The patients will undergo daily online adaptive re-optimisation of the radiotherapy treatment plan following daily recontouring.
Sponsors & Collaborators
-
Rigshospitalet, Denmark
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-11-21
- Primary Completion
- 2027-12-31
- Completion
- 2028-12-31
Countries
- Denmark
Study Locations
More Related Trials
-
A Study of Chemo +/- Low-dose Radiation as Induction Therapy in SCCHN
NCT02126969 ·Status: COMPLETED ·Phase: PHASE2
-
Docetaxel + Cetuximab + Concurrent Re-Irradiation (Intensity - Modulated Radiation Therapy, IMRT) for Patients With Locoregionally Recurrent Head and Neck Cancer
NCT00713219 ·Status: COMPLETED ·Phase: PHASE2
-
Carbon Ion Re-Radiotherapy in Patients With Recurrent or Progressive Locally Advanced Head-and-Neck Cancer
NCT04185974 ·Status: RECRUITING ·Phase: NA
-
Adaptive Radiation Treatment for Head and Neck Cancer
NCT01504815 ·Status: COMPLETED ·Phase: PHASE3
-
Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC
NCT00158652 ·Status: COMPLETED ·Phase: PHASE3
-
DAHANCA 37. Re-irradiation With Proton Radiotherapy
NCT03981068 ·Status: UNKNOWN ·Phase: NA
-
Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN
NCT03529422 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Accelerated Fractionation Radiotherapy (AFRT) Versus Concurrent Chemoradiotherapy (Crt) In Locally Advanced Head And Neck Squamous Cell Carcinoma
NCT01291095 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase II Study Exploring Five Fractions of Post-operative Radiation Therapy in Head and Neck Cancer
NCT05648461 ·Status: WITHDRAWN ·Phase: NA
-
Very Intense Radiotherapy-chemotherapy Regimen in Advanced HNSCC
NCT00162708 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Thermotherapy for Locally Advanced Head and Neck Cancer
NCT06761937 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Re-irradiation of Recurrent Head and Neck Cancer
NCT01973179 ·Status: ACTIVE_NOT_RECRUITING
-
Patient-Reported Outcomes in Head and Neck Cancer
NCT03918382 ·Status: RECRUITING ·Phase: NA
-
Induction TPN Followed by Nivolumab With Radiation in Locoregionally Advanced Laryngeal and Hypopharyngeal Cancer
NCT03894891 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Immunoradiotherapy in Head & Neck Cancer (NIRT 2-HNC)
NCT04938609 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Hypofractionated Radiotherapy for Postoperative Intermediate-Risk Head and Neck Squamous Cell Carcinoma
NCT07507058 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Study Evaluating a Stereotactic Boost/Treatment for Recurrent or Metastatic Cancer of the Head and Neck
NCT02474368 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
DAHANCA 19: The Importance of the EGFr-inhibitor Zalutumumab for the Outcome After Curative Radiotherapy for HNSCC
NCT00496652 ·Status: COMPLETED ·Phase: PHASE3
-
DAHANCA 35: Proton Versus Photon Therapy for Head-neck Cancer
NCT04607694 ·Status: UNKNOWN ·Phase: NA
-
High-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With Head and Neck Cancer
NCT00002555 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Accelerated RTH in Squamous Cell Carcinoma in Head and Neck
NCT05291663 ·Status: UNKNOWN
-
Chemoradiotherapy With Elective Low Dose Nodal Radiation for Locally Advanced Head and Neck Cancer
NCT01372111 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Immunoradiotherapy in Head & Neck Cancer
NCT03247712 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Chemotherapy Plus Radiation Therapy in Treating Patients With Squamous Cell Cancer of the Head and Neck
NCT00003200 ·Status: COMPLETED ·Phase: PHASE1
-
A Retrospective Clinical Study of Apatinib in Combination With Radiotherapy / Chemotherapy Second-line and Above in the Treatment of Recurrent / Metastatic Head and Neck Squamous Cell Carcinoma
NCT03424291 ·Status: UNKNOWN ·Phase: PHASE2