Effects of Microbiological and Immunological Factors on the Lower Urinary Tract

Summary

Millions of patients of all ages suffer worldwide from diverse urinary pathologies, such as lower urinary tract (LUT) dysfunction, bladder pain syndrome, urinary tract infections (UTIs), or bladder cancer. The research project investigates the interplay between the bladder and the microbiome. The goal is to evaluate the association of microbiological and immunological factors with lower urinary tract health in humans.

Conditions

• Asymptomatic Bacteriuria in Subjects Not Requiring Assisted Bladder Emptying
• Asymptomatic Bacteriuria in Subjects Relying on Some Type of Catheter
• Recurrent Non-catheter Associated UTIs
• Acute Catheter-associated UTI (CAUTI)
• Recurrent Catheter-associated UTI (CAUTI)
• Chronic Pelvic Pain
• Non-neurogenic Overactive Bladder Syndrome / LUT Symptoms
• Non-muscle-invasive Bladder Cancer

Sponsors & Collaborators

• Kessler Group

  collaborator UNKNOWN

• Rätsch Group

  collaborator UNKNOWN

• Slack Group

  collaborator UNKNOWN

• Boyman Group

  collaborator UNKNOWN

• Sunagawa Group

  collaborator UNKNOWN

• Zamboni Group

  collaborator UNKNOWN

• Loessner Group

  collaborator UNKNOWN

• McKinney Group

  collaborator UNKNOWN

• Nexus

  collaborator UNKNOWN

• Research Group Dirk Bumann

  collaborator UNKNOWN

• Research Group Christoph Dehio

  collaborator UNKNOWN

• University of Zurich

  lead OTHER

Principal Investigators

• Thomas Kessler, Prof. Dr. med. · Universitätsklinik Balgrist

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-06-01

Primary Completion

2026-11-30

Completion

2026-11-30

Countries

• Switzerland

Study Locations