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Renal and Hepatic Abnormal Doppler Patterns in Trauma

NCT07492511 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 350

Last updated 2026-03-25

No results posted yet for this study

Summary

The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma.

The main questions it aims to answer are:

* How reliably can trained operators measure renal Doppler and venous congestion scores (RDRI and VExUS) across different hospitals?
* How common are abnormal kidney and liver blood flow patterns in major trauma patients during the first 72 hours of ICU admission?
* Are these abnormal patterns associated with acute kidney injury or the need for mechanical ventilation?

Participants admitted to ICUs or high-dependency units (HDUs) with major trauma (Injury Severity Score \>15) will undergo non-invasive bedside ultrasound assessments at admission and at 24, 48, and 72 hours. No additional treatments or interventions will be given as part of this study. Kidney function will also be checked at 6 months after hospital discharge.

Conditions

Interventions

DIAGNOSTIC_TEST

Point of care ultrasound

Non-invasive bedside ultrasound assessment (renal Doppler and VExUS score) performed at baseline (≤6h from ICU admission), 24h, 48h, and 72h. No intervention is administered.

Sponsors & Collaborators

  • Azienda Usl di Bologna

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2029-12-31
Completion
2030-06-30

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07492511 on ClinicalTrials.gov