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Effect of Ambient Temperature on Blood Glucose and Insulin Absorption in Adults With Type 1 Diabetes

NCT07491133 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-03-24

No results posted yet for this study

Summary

The goal of this clinical trial is to learn how different temperatures affect blood sugar levels in adults with type 1 diabetes. Climate change is causing more extreme hot and cold weather, and people with type 1 diabetes may be at higher risk during these temperature changes. The main questions it aims to answer are:

* Do different temperatures (cold, normal, or hot) change blood sugar levels in people with type 1 diabetes?
* How does temperature affect insulin absorption in the body?

Researchers will compare three different temperature conditions to see how each affects blood sugar levels and insulin in the body.

Participants will:

* Complete a screening visit with body measurements and questionnaires
* Attend 3 separate study visits, each in a different temperature setting:
* Cold room (10°C/50°F)
* Normal room temperature (23°C/73°F)
* Hot and humid room (36°C/97°F with 65% humidity)
* Sit for 2 hours in each temperature condition while researchers monitor their blood sugar, heart rate, and body temperature
* Wear a continuous glucose monitor for 48-72 hours before each visit
* Keep a diary of food, sleep, and activity for 24 hours before and after each visit

Each temperature visit is separated by at least 3 days. The study helps researchers understand if people with type 1 diabetes need special guidance for managing their blood sugar during extreme weather.

Conditions

  • Type 1 Diabetes Mellitus

Interventions

OTHER

Environmental Temperature Exposure

Systematic exposure to controlled temperature and humidity conditions in a specialized environmental chamber. Each exposure lasts 120 minutes with participants remaining seated throughout. All exposures include standardized pre-exposure preparation (60-minute baseline period at room temperature), continuous physiological monitoring, standardized clothing, and identical blood sampling schedules. Safety protocols include continuous staff supervision, predetermined stopping criteria for extreme body temperatures or blood pressure changes, and immediate availability of warming/cooling interventions and hypoglycemia treatment protocols.

Sponsors & Collaborators

  • Cardiometabolic Health, Diabetes and Obesity Research Network

    collaborator UNKNOWN

  • Centre EPIC

    collaborator UNKNOWN

  • Institut de Recherches Cliniques de Montreal

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2027-03-31
Completion
2027-07-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07491133 on ClinicalTrials.gov