Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore

Summary

The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early identification and targeted interventions can improve health outcomes and support healthy ageing. The main questions it aims to answer are:

* Can combined frailty and intrinsic capacity screening with targeted interventions prevent or reduce functional decline in older adults, as measured by changes in life space mobility?
* Will at least 80% of screened older adults adhere to recommended care pathways and interventions?
* Can this screening and intervention programme demonstrate sustainability through continued community participation and recruitment of new partner organizations beyond the initial implementation phase? The investigators will compare an intervention group (receiving immediate assessment and clinical referrals based on identified needs) to a wait-list control group (receiving the same interventions 12 months later) to see if early intervention leads to better health outcomes and quality of life.

Participants will:

* Attend 4 study visits over 2 years (at 6-monthly intervals in the first year, with final assessment at end of year 2), each lasting up to 2 hours.
* Undergo comprehensive screening assessments including mobility, cognition, mental health, hearing, vision, and nutritional status.
* Receive 2 follow-up phone calls at 3-month and 9-month intervals to monitor progress.
* If in the intervention group: receive personalized referrals for further care (which may include comprehensive geriatric assessment, primary care reviews, rehabilitation, or dietitian consultations) and guidance on using a mobile health monitoring application.
* If in the wait-list control group: receive the same interventions after their 3rd study visit (12 months later).

Conditions

• Frailty in Older Adults
• Intrinsic Capacity
• Age-related Functional Decline
• Healthy Ageing

Interventions

OTHER

INFINITY-ICOPE programme

The INFINITY-ICOPE programme will involve (i) integrated frailty and intrinsic capacity screening, (ii) referral to comprehensive geriatric assessment for frail participants or pathways adapted from the WHO-ICOPE approach for non-frail seniors with intrinsic capacity decline, (iii) 6-monthly self-monitoring for IC and frailty supported through the ENGAGE app and SCREENii.

Sponsors & Collaborators

• Singapore Health Services

  collaborator OTHER

• Singapore General Hospital

  collaborator OTHER

• Changi General Hospital

  collaborator OTHER

• SingHealth Polyclinics

  collaborator OTHER

• National Dental Centre, Singapore

  collaborator OTHER

• Geriatric Education and Research Institute

  collaborator OTHER_GOV

• National University of Singapore

  collaborator OTHER

• Singapore University of Social Sciences

  collaborator OTHER

• Sengkang General Hospital

  lead OTHER

Principal Investigators

• Laura Bee Gek Tay · Sengkang General Hospital

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-07-17

Primary Completion

2027-06-30

Completion

2028-01-15

Countries

• Singapore

Study Locations