MedTrace Logo

Predictors of Androgen Status Decline in Middle-Aged Men

NCT07476222 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2026-05-18

No results posted yet for this study

Summary

Age-related decrease in testosterone levels in men is associated with multiple metabolic, functional and psychosocial consequences. Early identification of modifiable factors associated with decreased testosterone levels may contribute to improved prevention of androgen deficiency and related health conditions.

This population-based analytical cross-sectional observational study aims to investigate anthropometric, functional and lifestyle-related factors associated with decreased total testosterone levels in middle-aged men. Approximately 600 men aged 35-59 years residing in the Andijan region of Uzbekistan will be recruited.

Participants will undergo comprehensive assessment including anthropometric measurements, functional performance tests, standardized questionnaires and laboratory determination of serum total testosterone levels. Anthropometric variables will include body mass index, waist circumference, hip circumference, waist-to-hip ratio and waist-to-height ratio. Functional status will be assessed using hand-grip strength, five-times chair-stand test, 4-meter walk test, balance assessment and the six-minute walk test. Lifestyle-related factors including physical activity, sleep quality, dietary habits, smoking, alcohol consumption and psychoemotional status will be evaluated using validated questionnaires.

The study aims to identify determinants of decreased testosterone levels and develop a predictive model for early identification of androgen deficiency in middle-aged men.

Conditions

  • Testosterone Deficiency
  • Androgen Deficiency
  • Male Hypogonadism
  • Late-Onset Hypogonadism

Interventions

OTHER

Observational Assessment

Participants undergo standardized anthropometric measurements, functional performance tests, validated questionnaires assessing lifestyle-related and psychoemotional factors, and laboratory determination of serum total testosterone levels. No therapeutic or preventive intervention is administered.

Sponsors & Collaborators

  • Tashkent Medical Academy

    collaborator OTHER

  • Andijan State Medical Institute

    lead OTHER

Principal Investigators

  • Abdukhalim Kh. Abdurakhimov, PhD · Andijan State Medical Institute

Eligibility

Min Age
35 Years
Max Age
59 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • Uzbekistan

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07476222 on ClinicalTrials.gov