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Evaluation of Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis

NCT07471204 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 34

Last updated 2026-03-17

No results posted yet for this study

Summary

Knee osteoarthritis (OA) is a degenerative joint disease characterized by pain, muscle weakness, and functional limitations that significantly affect lower limb muscle performance. Structural and physiological alterations in the quadriceps muscle, particularly in the vastus medialis obliquus (VMO), have been reported in individuals with knee OA, including reductions in muscle cross-sectional area, intramuscular fat infiltration, vascular changes, and impaired neuromuscular activation.

Muscle oxygenation (SmO₂) is an objective indicator of the metabolic status and circulatory capacity of skeletal muscle. However, the oxygenation dynamics of the quadriceps muscle before and after exercise in individuals with knee OA have not been sufficiently investigated.

The aim of this study is to evaluate VMO muscle oxygenation at rest, during exercise, and during the recovery period in individuals with knee OA and to compare these parameters with age- and sex-matched healthy individuals. In addition, the study will examine the relationship between muscle oxygenation parameters, muscle strength, functional performance, and pain levels.

Understanding these physiological responses may provide insight into the metabolic mechanisms underlying muscle dysfunction in knee OA and may contribute to the development of more individualized rehabilitation strategies.

Conditions

  • Osteoarthritis of Knee
  • Healthy Participants

Interventions

OTHER

No intervention

15-repetition mini-squat exercise is used only as an assessment task.

Sponsors & Collaborators

  • Istanbul University - Cerrahpasa

    collaborator OTHER

  • Istanbul Aydın University

    collaborator OTHER

  • Bahçeşehir University

    lead OTHER

Principal Investigators

  • Ayşem Ecem Özdemir, PT, Msc · Bahçeşehir University

  • Yıldız Analay Akbaba, PT, PhD · Istanbul University - Cerrahpasa

  • Gökhan Özkoçak, MD, PhD · Istanbul Aydın University

Eligibility

Min Age
45 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2026-08-01
Completion
2026-09-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07471204 on ClinicalTrials.gov