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Sleep, Light, Circadian, Central Oxidative Stress

NCT07471126 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-03-13

No results posted yet for this study

Summary

Irregular sleep timing and sleep deficiency are pervasive in society despite evidence that sleep deficiency impairs cognition and is linked to neurodegenerative disease. Potential pathways underlying the adverse cognitive function and brain health associated with irregular insufficient sleep include misalignment of sleep from the internal \~24-hour body clock and brain oxidative stress. This research will investigate these putative pathways and inform future interventions to mitigate the impact of sleep loss on cognition and brain health.

Conditions

  • Non-visual Effects of Light
  • Chronic Variable Sleep Deficiency

Interventions

BEHAVIORAL

Room light

\~90 lux ambient lighting while awake

BEHAVIORAL

Control sleep

Nightly 8-h sleep opportunity

BEHAVIORAL

Chronic Variable Sleep Deficiency

Repeated cycles of sleep restriction followed by recovery sleep.

BEHAVIORAL

Sleep- and Circadian-Informed Lighting

Ambient visible light exposure with modulated intensity and spectrum

BEHAVIORAL

Dim Light

\<3 lux dim ambient lighting while awake

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-30
Primary Completion
2029-03-30
Completion
2029-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07471126 on ClinicalTrials.gov