MedTrace Logo

Povidone-Iodine Nasal Irrigation After Surgery for Chronic Rhinosinusitis

NCT07470242 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2026-03-13

No results posted yet for this study

Summary

This prospective randomized controlled trial evaluates the effectiveness and safety of different nasal irrigation solutions for postoperative care after endoscopic sinus surgery in patients with chronic rhinosinusitis. Patients undergoing endoscopic sinus surgery will be randomly assigned to receive nasal irrigation with normal saline, mucomyst, or diluted povidone-iodine solution for three months after surgery. Clinical outcomes, symptom scores, endoscopic findings, and potential ototoxic effects will be evaluated to compare the effectiveness and safety of these irrigation methods.

Conditions

  • Chronic Rhinosinusitis

Interventions

OTHER

Normal Saline Nasal Irrigation

Postoperative nasal irrigation using normal saline solution for 3 months after endoscopic sinus surgery.

DRUG

Acetylcysteine (Mucomyst) Nasal Irrigation

Postoperative nasal irrigation using acetylcysteine solution for 3 months after endoscopic sinus surgery.

DRUG

Povidone-Iodine Nasal Irrigation

Postoperative nasal irrigation using diluted 0.5% povidone-iodine solution for 3 months after endoscopic sinus surgery.

Sponsors & Collaborators

  • Pusan National University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-13
Primary Completion
2023-03-07
Completion
2023-08-07

Countries

  • South Korea

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07470242 on ClinicalTrials.gov